منابع مشابه
Lp-PLA2 levels in HIV-infected patients
INTRODUCTION HIV-infected patients show an increased risk of cardiovascular disease (CVD). In the general population, lipoprotein-associated phospholipase A2 (Lp-PLA2) appears to be an independent predictor of CVD. We aimed to study associations between Lp-PLA2 plasma levels and other risk factors for CVD in HIV patients. MATERIALS AND METHODS A cross-sectional, comparative study of two serie...
متن کاملLipoprotein-associated phospholipase A2 (Lp-PLA2)
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متن کاملLipoprotein-associated phospholipase A2 (Lp-PLA2)
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متن کاملLp-PLA2 Inhibition—The Atherosclerosis Panacea?
Based on the complex pathophysiology of atherosclerosis, a large number of biomarkers that relate to lipids, inflammation, immunity, thrombosis and hemostasis, have been investigated experimentally, in epidemiologic studies and in clinical trials. Interest focuses on their potential role to aid in risk stratification, as possible surrogate markers of atherosclerosis, and potential targets for t...
متن کاملGenetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles
Aims Darapladib, a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2), has not reduced risk of cardiovascular disease outcomes in recent randomized trials. We aimed to test whether Lp-PLA2 enzyme activity is causally relevant to coronary heart disease. Methods In 72,657 patients with coronary heart disease and 110,218 controls in 23 epidemiological studies, we genotyped five ...
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ژورنال
عنوان ژورنال: médecine/sciences
سال: 2014
ISSN: 0767-0974,1958-5381
DOI: 10.1051/medsci/20143005015