Lp-PLA2 et sPLA2

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Lp-PLA2 levels in HIV-infected patients

INTRODUCTION HIV-infected patients show an increased risk of cardiovascular disease (CVD). In the general population, lipoprotein-associated phospholipase A2 (Lp-PLA2) appears to be an independent predictor of CVD. We aimed to study associations between Lp-PLA2 plasma levels and other risk factors for CVD in HIV patients. MATERIALS AND METHODS A cross-sectional, comparative study of two serie...

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Lipoprotein-associated phospholipase A2 (Lp-PLA2)

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Lipoprotein-associated phospholipase A2 (Lp-PLA2)

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Lp-PLA2 Inhibition—The Atherosclerosis Panacea?

Based on the complex pathophysiology of atherosclerosis, a large number of biomarkers that relate to lipids, inflammation, immunity, thrombosis and hemostasis, have been investigated experimentally, in epidemiologic studies and in clinical trials. Interest focuses on their potential role to aid in risk stratification, as possible surrogate markers of atherosclerosis, and potential targets for t...

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Genetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles

Aims Darapladib, a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2), has not reduced risk of cardiovascular disease outcomes in recent randomized trials. We aimed to test whether Lp-PLA2 enzyme activity is causally relevant to coronary heart disease. Methods In 72,657 patients with coronary heart disease and 110,218 controls in 23 epidemiological studies, we genotyped five ...

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ژورنال

عنوان ژورنال: médecine/sciences

سال: 2014

ISSN: 0767-0974,1958-5381

DOI: 10.1051/medsci/20143005015